The article “August JADA Explores Saliva-Based Testing,” was very interesting. Unfortunately, what was omitted from the article was which clinical applications it could be used for. It indicated that it could be used for systemic disease determination, such as cancer. Might it be used to confirm a bacterial or viral infection? Could it tell us if the saliva components of an individual had a predilection for dental caries? Might it confirm the presence or level of periodontal disease? Would it tell if an oral ulcer is carcinogenic or if the oral lesion represents an indication that an autoimmune disease is the causative factor? Read the full article.